diff --git a/CHANGELOG.md b/CHANGELOG.md
index 04ecfc87..93c11d66 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `wasmtime@latest` to 21.0.1.
+
 ## [2.33.27] - 2024-05-21
 
 - Update `wasmtime@latest` to 21.0.0.
diff --git a/manifests/wasmtime.json b/manifests/wasmtime.json
index d9a317a6..8865484c 100644
--- a/manifests/wasmtime.json
+++ b/manifests/wasmtime.json
@@ -23,13 +23,30 @@
     }
   },
   "latest": {
-    "version": "21.0.0"
+    "version": "21.0.1"
   },
   "21": {
-    "version": "21.0.0"
+    "version": "21.0.1"
   },
   "21.0": {
-    "version": "21.0.0"
+    "version": "21.0.1"
+  },
+  "21.0.1": {
+    "x86_64_linux_gnu": {
+      "checksum": "d49619e38c660196a048e80d34292e458a11af010ab1780e7b3ae9a42df6e33b"
+    },
+    "x86_64_macos": {
+      "checksum": "8452dc6e865553cc7027d45a961f86440fd9459de7a48117236c386e4ceb2a1f"
+    },
+    "x86_64_windows": {
+      "checksum": "c2a1e23e2ab49f3f942e6a47aba8c60c863fd66166c3940fa3dd1f9a0286a4b6"
+    },
+    "aarch64_linux_gnu": {
+      "checksum": "77e8a381bbc54f39399c71ee305b6ce5b6807e7c088846ea1e406a3a62b38146"
+    },
+    "aarch64_macos": {
+      "checksum": "816a4a50c875de0804c316fc3171fb20a45fb82e4bf3e3313dec4f6d819df688"
+    }
   },
   "21.0.0": {
     "x86_64_linux_gnu": {