diff --git a/CHANGELOG.md b/CHANGELOG.md
index 25db74e4..a6d11f8d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `mise@latest` to 2026.2.21.
+
 ## [2.68.11] - 2026-02-26
 
 - Update `wasmtime@latest` to 42.0.1.
diff --git a/manifests/mise.json b/manifests/mise.json
index c02b3fc8..69125bee 100644
--- a/manifests/mise.json
+++ b/manifests/mise.json
@@ -28,13 +28,39 @@
   },
   "license_markdown": "[MIT](https://github.com/jdx/mise/blob/main/LICENSE)",
   "latest": {
-    "version": "2026.2.20"
+    "version": "2026.2.21"
   },
   "2026": {
-    "version": "2026.2.20"
+    "version": "2026.2.21"
   },
   "2026.2": {
-    "version": "2026.2.20"
+    "version": "2026.2.21"
+  },
+  "2026.2.21": {
+    "x86_64_linux_musl": {
+      "etag": "0x8DE75289D8B14FE",
+      "checksum": "b14d6e1e2422bd861fec822f59fcde29d4338172c03b115c47abc8de55129cba"
+    },
+    "x86_64_macos": {
+      "etag": "0x8DE75289FBB5DB9",
+      "checksum": "fe6debbbda420b671057ee06a68cee89e4334b2f5d60566ea60095244c72d1d3"
+    },
+    "x86_64_windows": {
+      "etag": "0x8DE7528A0889C6F",
+      "checksum": "765d8fc64cc2fa032a67b3ac2dd5fc9bf3bf1217549a10c8869a0cb9881a7c61"
+    },
+    "aarch64_linux_musl": {
+      "etag": "0x8DE75289A4736A2",
+      "checksum": "eb639659b84184dba5375fef6747f7cdfadb14dc0dcf00ab659573a2c1fa410e"
+    },
+    "aarch64_macos": {
+      "etag": "0x8DE75289EE7E46C",
+      "checksum": "113a6c79b078e4cd9aafe50d3cb0f8e7ae40d9c90dc50205d4e955ddf4138402"
+    },
+    "aarch64_windows": {
+      "etag": "0x8DE7528A018A564",
+      "checksum": "81756708a3151480e922d626bfc4638a8a922dd0dfffd52c8df66b56d42bf5c4"
+    }
   },
   "2026.2.20": {
     "x86_64_linux_musl": {