diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5f5770f6..7db81f18 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `mise@latest` to 2025.9.21.
+
 - Update `just@latest` to 1.43.0.
 
 ## [2.62.10] - 2025-09-27
diff --git a/manifests/mise.json b/manifests/mise.json
index b3a229e4..d0099d8e 100644
--- a/manifests/mise.json
+++ b/manifests/mise.json
@@ -28,13 +28,39 @@
   },
   "license_markdown": "[MIT](https://github.com/jdx/mise/blob/main/LICENSE)",
   "latest": {
-    "version": "2025.9.20"
+    "version": "2025.9.21"
   },
   "2025": {
-    "version": "2025.9.20"
+    "version": "2025.9.21"
   },
   "2025.9": {
-    "version": "2025.9.20"
+    "version": "2025.9.21"
+  },
+  "2025.9.21": {
+    "x86_64_linux_musl": {
+      "etag": "0x8DDFE1B3D6F489A",
+      "checksum": "9e44d1eb151b172fbdfa4b9e875bb0417d60fdc948e7b515eb8e8dc2195ef6e1"
+    },
+    "x86_64_macos": {
+      "etag": "0x8DDFE1B3F0AAEED",
+      "checksum": "ecfff13b26d721a57dd0a6648b2ab4b715f4a0656712672b95af33184bd12faa"
+    },
+    "x86_64_windows": {
+      "etag": "0x8DDFE1B3FA9E541",
+      "checksum": "ec88f138c1af5c6443fbb6fd36292613103a5c504e163fc769c88372923b1c8a"
+    },
+    "aarch64_linux_musl": {
+      "etag": "0x8DDFE1B3AE510C5",
+      "checksum": "132d2f7d99cadb884b47f27bcf02c6b8b8a3175f146e0568f7acd156637f8256"
+    },
+    "aarch64_macos": {
+      "etag": "0x8DDFE1B3E494A07",
+      "checksum": "824f241e24ae8afdba8561a8a29329dbb08ee6bc72b60d2eb862ae30f3b0de85"
+    },
+    "aarch64_windows": {
+      "etag": "0x8DDFE1B3F9F1BF7",
+      "checksum": "03d3458ee92e093864f5e18f6b7ab5e259598f19d02a8079b21586becc7fa0ca"
+    }
   },
   "2025.9.20": {
     "x86_64_linux_musl": {